In lieu of an abstract, here is a brief excerpt of the content:Ideas in the Brain: The Localization of Memory Traces in the Eighteenth CenturyTimo KaitaroPlato suggests in the Theaetetus that we imagine a piece of wax in our soul, a gift from the goddess of Memory. We are able to remember things when our perceptions or thoughts imprint a trace upon this piece of wax, in the same manner as a seal is stamped on wax. Plato (...) uses this metaphor to explain the errors which arise when we mistake something for something else: we connect the perception of an object with the trace belonging to another. The metaphor can also be used in explaining differences in people’s mnestic capacities: rapid learning and forgetting correspond to soft wax, impure wax results in muddled traces, etc.1 If we locate the traces in the brain instead of in the soul, Plato’s metaphor gains consistency and turns into a testable hypothesis. This move was already made by Quintilian.2So, the metaphor of memory as traces in the brain is evidently not a modern invention. This is easy to understand. To frame the hypothesis one needs only to reflect on how we use objects outside our brains for mnemonic purposes. We conserve ideas by tracing or printing letters and words on paper. We are also able to conserve images in drawings, paintings and prints. What could be more natural than to think of memory as the formation of traces in the brain? The development of even better information storage techniques in the form of pictures, symbols, and signs provides the metaphor extra plausibility. Plato’s seal allows us to imagine the imprint of a person’s likeness, but modern techniques of information storage and retrieval make it even easier to imagine memory in general as the formation of material traces.Explaining memory in terms of material traces could, of course, be taken [End Page 301] to mean that the formation of material traces in the brain is merely a necessary condition of memory. But one could also take a more reductionistic stance which identifies memory with the formation of material traces. Furthermore, one could identify specific mental items (sensations, ideas, memories) with specific physiological events or anatomical entities in the brain. This seems especially plausible if we imagine that the traces in the brain are as discrete and separate as ideas or memories are in our minds. Since the traces we form or print on paper consist of discrete letters and words, the thought that the traces in the brain are equally discrete and separate comes easily. Plato, in fact, made separateness a condition for the memory to work properly: it is not easy to read signs printed on one another.3 Of course, no traces are actually visible in the brain. But they are easy to imagine, as it is to imagine explanations of psychological phenomena, such as association, based on these traces.At the end of the seventeenth century, explanations of mental phenomena referring to material traces in the brain were used by writers, from Platonists to materialists, who supported widely different theories about the nature of the human mind.4 In fact, as I will show later in this paper, the question of the possible identity of mental entities, like ideas or sensations, with material entities or traces in the brain is relatively independent of the question of the existence of an immaterial soul. Or rather, if there is a systematic connection between the answers proposed to these two questions in the eighteenth century, it is not the connection one would expect. Nowadays we often tend to think of a prototypical materialist as someone who makes radical reductionistic claims about the identity of mental phenomena with brain states. We also tend to think of the eighteenth-century French materialists as “mechanistic.”5 In view of this reputation, it may come as a surprise to find that some eighteenth-century materialists, notably Denis Diderot, were in fact consistent anti-reductionists and opposed to mechanical or mechanistic explanations of the mental.6 In fact, the epithet “mechanistic” is misleading even when applied to the philosopher who is traditionally presented as the paradigmatic example of a “mechanistic materialist,” Julien Offray... (shrink)

The emphasis placed by H. Atlan, like G. Bateson, on the reception of messages during communication between subsystems leads to a conception of learning, and more generally of human memory, surprisingly close to that proposed by I. Rosenfield on the basis of the work of G. M. Edelman. The authors stressed the close and reciprocal link between the theory of functional localization and the conception of memory, which they have just seen, radically refuted by Rosenfield. The theory (...) of functional localization therefore considers as established the existence of a whole series of rigid relationships between specific locations in the brain and certain major functions performed by the body. Thus briefly summarized, the theory of neural Darwinism provides positive evidence in favor of the Rosenfield's theory of human memory. All these characteristics make the functioning of human memory an outstanding example of the natural complexity of a self‐organized system in the sense of Atlan. (shrink)

Ranging from behavioral to molecular levels of analysis, this informative study presents the results of recent research into the biochemistry and neural mechanisms of imprinting. Horn discusses some of the difficulties that researchers have encountered in analyzing the neural basis of memory and describes ways in which these difficulties have been overcome through the analysis of memories underlying habituation and imprinting. He also considers the biochemical consequences of imprinting and its cerebral localization, and examines the relationships between human (...) and animal memory. (shrink)

This chapter makes an introduction that focuses on the spirit of Henri Bergson's philosophy organized around his ambition to affect a transformation of life. His first major work, Time and Free Will (1888) examines the effect of a spatialized view of time come to dominate human life, infecting philosophy with a false dilemma regarding the freedom of the human will and social life with conformity. His second work, Matter and Memory (1896), examines the effects of the human condition and (...) scientism on our understanding of the relation between mind and body and the source of consciousness, memory, and dreams in neural correlates or stored in the brain, as Bergson put it when discussing what he called the problem of localization. Creative evolution (1907) rejects the closed systems of all kinds – naturalism, evolutionism, finalism, materialism, idealism – that deny the essential creativity and novelty of life. (shrink)

Visual working memory is a construct hypothesized to store a small amount of accurate perceptual information that can be brought to bear on a task. Much research concerns the construct's capacity and the precision of the information stored. Two prominent theories of VWM representation have emerged: slot-based and continuous-resource mechanisms. Prior modeling work suggests that a continuous resource that varies over trials with variable capacity and a potential to make localization errors best accounts for the empirical data. Questions (...) remain regarding the variability in VWM capacity and precision. Using a novel eye-tracking paradigm, we demonstrate that VWM facilitates search and exhibits effects of fixation frequency and recency, particularly for prior targets. Whereas slot-based memory models cannot account for the human data, a novel continuous-resource model does capture the behavioral and eye tracking data, and identifies the relevant resource as item activation. (shrink)

La mondialisation économique qui définit nos sociétés contemporaines comme globales a entraîné une rencontre de la traduction avec les technologies, de façon à les adapter aux diverses situations locales. Dénommée tout d'abord « localisation » dans certains milieux professionnels, cette rencontre s'est vite complexifiée en incluant d'abord l'industrie de l'informatique puis divers marchés , affectant manifestement des secteurs entiers de la communication et de notre organisation sociale. Cet article traite plusieurs des faits marquants de cette rencontre de l'Internet et des (...) nouvelles technologies de l'information et de la communication avec la traduction, qui est devenue une composante majeure de l'internationalisation des produits et des services.Economic globalization that defines our contemporary societies as global resulted in a meeting with the translation technologies, so as to adapt them to different local situations. First called "localization" in some professional circles, this meeting was quickly complicated by including first the computer industry and various markets , Clearly affecting sectors whole communication and social organization. This article discusses several of the highlights of this meeting of the Internet and new information technologies and communications with the translation, which became a major component of the internationalization of products and services. (shrink)

Given a cofinal cardinal function $h\in {}^{\kappa }\kappa $ for $\kappa $ inaccessible, we consider the dominating h-localisation number, that is, the least cardinality of a dominating set of h-slaloms such that every $\kappa $ -real is localised by a slalom in the dominating set. It was proved in [3] that the dominating localisation numbers can be consistently different for two functions h (the identity function and the power function). We will construct a $\kappa ^+$ -sized family of functions h (...) and their corresponding localisation numbers, and use a ${\leq }\kappa $ -supported product of a cofinality-preserving forcing to prove that any simultaneous assignment of these localisation numbers to cardinals above $\kappa $ is consistent. This answers an open question from [3]. (shrink)

In this journal, Bucci (2022) has argued that two famous experiments in the neuroscientific literature can be used to support property dualism about the mind. In what follows, I attempt to illustrate that those experiments are completely compatible with a naive identity mind-brain/body identity theory.

We reimplement the creature forcing construction used by Fischer et al. :1045–1103, 2017. https://doi.org/10.1007/S00153-017-0553-8. arXiv:1402.0367 [math.LO]) to separate Cichoń’s diagram into five cardinals as a countable support product. Using the fact that it is of countable support, we augment our construction by adding uncountably many additional cardinal characteristics, sometimes referred to as localisation cardinals.

The discovery of the engram, the physical substrate of memory, is a central challenge for the sciences of memory. Following the application of optogenetics to the neurobiological study of memory, scientists and philosophers claim that the engram has been found. In this paper, I evaluate the implications of applying optogenetic tools to the localization of the engram. I argue that conceptions of engram localization need to be revised to be made consistent with optogenetic studies of (...) the engram. I distinguish between challenges to vehicle and content localization. First, I consider the silent engram hypothesis. According to this hypothesis, optogenetic studies indicate that synaptic efficacy, the traditional engram-bearing vehicle, is important merely for retrieval. I argue that this interpretation rests upon a misunderstanding of accessibility. Second, I argue that optogenetic-based strategies and findings conflict with preservationist and constructivist views on memory storage. There is an enduring trace, but stored content may change over time and experience, resulting in doubt about what constitutes a single engram. (shrink)

The analysis of demonstration locations classified by degree of urbanization shows that demonstrating is an urban phenomenon. Seldom are demonstrations held in thinly populated residential areas. A demonstration can thus be considered among the farms of political action for which the participation stimulating factors are clearly more present in urban areas than in rural areas.The distribution of the demonstrations over the regions indicates that more demonstrating is done in Flanders than in Wallonia. Flemings and 'walloons, moreover, appeared in the streets (...) for different points of confiict during the period from 1953 to 1974.Demonstrations with ideological themes overwhelmingly, and communitarian themes mostly, occurred in Flanders ; demonstrations for socioeconomic purposes occurred mostly in Wallonia. Demonstrations in the capital, Brussels, had the most participants on the average in general andalso for the three conflict areas. (shrink)

This paper deals with the notion of virtual memory in Bergson?s philosophy, with special regard to the question of the independence of memory and the complex intertwining of spiritual recollections with perception. Attention is devoted to the Bergsonian analysis of the actualization of virtual contents. The author also confronts the Bergsonian notion of unconscious with that of Freud?s. It seems that the notion of virtual memory is relevant not only from a psychological or an epistemological perspective, but (...) it has also some consequences with regard to practical philosophy. An excursus is devoted to the Deleuzien interpretation of virtuality. At the end of the paper the author discusses the immanent tensions within the Bergsonian concept of virtual memory from the aspect of temporal verticality, the impossible localization of virtuality and freedom. Clanak se bavi pojmom virtuelne memorije u Bergsonovoj filozofiji, sa posebnim osvrtom na pitanje o samostalnosti secanja i na slozeno ukrstanje duhovnih uspomena sa konkretnom percepcijom. Posebna paznja usmerena je na Bergsonovu analizu o aktuelizaciji virtuelnih sadrzaja. Autor takodje sprovodi konfrontaciju Bergsonovog pojma nesvesnog sa Frojdovim shvatanjem istog. Pokazuje se da pojam virtuelne memorije nije relevantan samo iz psiholoske ili epistemoloske perspektive, vec da on ima izvesne konsekvence i u pogledu prakticke filozofije. Delezovoj interpretaciji virtuelnog je posvecen poseban ekskurs. Na kraju se ukazuje na unutrasnje napetosti Bergsonovog shvatanja virtuelne memorije iz aspekta vremenske vertikalnosti i nemoguce lokalizacije virtuelnog, odnosno, slobode. (shrink)

An analysis of two heuristic strategies for the development of mechanistic models, illustrated with historical examples from the life sciences. In Discovering Complexity, William Bechtel and Robert Richardson examine two heuristics that guided the development of mechanistic models in the life sciences: decomposition and localization. Drawing on historical cases from disciplines including cell biology, cognitive neuroscience, and genetics, they identify a number of "choice points" that life scientists confront in developing mechanistic explanations and show how different choices result in (...) divergent explanatory models. Describing decomposition as the attempt to differentiate functional and structural components of a system and localization as the assignment of responsibility for specific functions to specific structures, Bechtel and Richardson examine the usefulness of these heuristics as well as their fallibility—the sometimes false assumption underlying them that nature is significantly decomposable and hierarchically organized. When Discovering Complexity was originally published in 1993, few philosophers of science perceived the centrality of seeking mechanisms to explain phenomena in biology, relying instead on the model of nomological explanation advanced by the logical positivists (a model Bechtel and Richardson found to be utterly inapplicable to the examples from the life sciences in their study). Since then, mechanism and mechanistic explanation have become widely discussed. In a substantive new introduction to this MIT Press edition of their book, Bechtel and Richardson examine both philosophical and scientific developments in research on mechanistic models since 1993. (shrink)

The central aim of this book is to understand modules and the categories they form through associated structures and dimensions, which reflect the complexity of these, and similar, categories.

Ageing populations and rising rates of chronic disease globally have shifted key elements of disease management to ideas of integrated care and self‐management. The associated policies and programmes often focus on intervention and support beyond the sites of the hospital and clinic. These shifts have significantly impacted the delivery and practice of nursing for both nurses and the clients with whom they work. This article argues that Foucault's comments on space, place and heterotopia (1986) are useful in exploring these changes (...) from a philosophical perspective, to draw out the complexity of these programmes and add texture to discussions on the ways these shifts to localisation and the dominant discourses of self‐management and responsibility have reconfigured nursing practices. The theoretical discussion is augmented with illustrations from an Australian integrated health care programme. (shrink)

The main topics of this second part of a two-part essay are some consequences of the phenomenon of vacuum polarization as the most important physical manifestation of modular localization. Besides philosophically unexpected consequences, it has led to a new constructive “outside-inwards approach” in which the pointlike fields and the compactly localized operator algebras which they generate only appear from intersecting much simpler algebras localized in noncompact wedge regions whose generators have extremely mild almost free field behavior. -/- Another consequence (...) of vacuum polarization presented in this essay is the localization entropy near a causal horizon which follows a logarithmically modified area law in which a dimensionless area (the area divided by the square of dR where dR is the thickness of a light-sheet) appears. There are arguments that this logarithmically modified area law corresponds to the volume law of the standard heat bath thermal behavior. We also explain the symmetry enhancing effect of holographic projections onto the causal horizon of a region and show that the resulting infinite dimensional symmetry groups contain the Bondi–Metzner–Sachs group. This essay is the second part of a partitioned longer paper. (shrink)

RNA localization is a powerful strategy used by cells to localize proteins to subcellular domains and to control protein synthesis regionally. In germ cells, RNA targeting has profound implications for development, setting up polarities in genetic information that drive cell fate during embryogenesis. The frog oocyte offers a useful system for studying the mechanism of RNA localization. Here, we discuss critically the process of RNA localization during frog oogenesis. Three major pathways have been identified that are temporally (...) and spatially separated in oogenesis. Each pathway uses a different mechanism to effect RNA localization. In some cases, localization elements within the 3' untranslated region have been identified and have provided unique insights into the localization process. This important field is still in its infancy, however, and much remains to be learned. BioEssays 21:546–557, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

Recent genetic manipulations have revealed that the cytoplasm of the early Drosophila embryo contains localized information that specifies the future embryonic axes. It is the restricted distribution or activity of particular gene products, either messenger RNA or protein, that is crucial for this specification. While some of the genes responsible for this information have been seqenced and the nature and distribution of their products examined, it is not known how this localization is established or maintained. The actin‐based cytoskeleton is (...) a likely candidate for the formation of a cytomatrix that would allow such distributions and yet no direct evidence has yet been found that implicates actin in positional cue localization. In this review I summarize what is known about actin filament behavior. in Drosophila embryos and compare it to the distribution of positional cues. My purpose is to juxtapose these two bodies of information such that the relationship between them may be revealed. (shrink)

The progression of theories suggested for our world, from ego- to geo- to helio-centric models to universe and multiverse theories and beyond, shows one tendency: The size of the described worlds increases, with humans being expelled from their center to ever more remote and random locations. If pushed too far, a potential theory of everything (TOE) is actually more a theories of nothing (TON). Indeed such theories have already been developed. I show that including observer localization into such theories (...) is necessary and sufficient to avoid this problem. I develop a quantitative recipe to identify TOEs and distinguish them from TONs and theories in-between. This precisely shows what the problem is with some recently suggested universal TOEs. (shrink)

Spontaneous localization theories are a class of quantum theories which solve the so-called measurement problem by non-linearly and stochastically modifying the Schrödinger dynamics. In this paper I briefly explain where these theories are coming from, what their driving ideas and main features are, and how they were historically developed. Also, I discuss their empirical and ontological adequacy, as well as their relativistic extensions and their experimental confirmation.

Spontaneous localization theory is a quantum theory proposed by GianCarlo Ghirardi, together with Alberto Rimini and Tullio Weber in 1986. However, soon it became clear to Ghirardi that his work was more than just one theory: he actually developed a framework, a family of theories in which the wavefunction jumps, but where the ontology of the theory is underdetermined. After acknowledging that the wavefunction did not provide a satisfactory ontology, he assumed that matter was described by a continuous matter (...) density field in three-dimensional space, whose evolution is governed by a stochastic wavefunction evolution. Alternatively, Bell assumed that the wavefunction would govern a spatiotemporal event ontology, dubbed ‘flashes.’ However, not much work has been done with the perhaps most obvious possibility, namely that physical objects are made of particles. This paper has two aims. First to explain the reason why people require spontaneous localization theory to be more than just a theory about the wavefunction. This is done by showing how the problem everyone in the foundation of quantum mechanics take to be the fundamental problem of quantum mechanics, namely the measurement problem, is a red herring. Then, the paper explores the possibility of spontaneous localization theories of particles. I argue that this discussion is not a mere exercise, as spontaneous localization theories of particles may be amenable to a relativistic extension which does not require a foliation, and because in general the peculiar type of indeterminism of spontaneous localization theories may help shedding new light on the nature of the tension between quantum theory and relativity. (shrink)

Global Health involves, among many things the intensified travelling of people, resources, technologies, knowledge, standards, and ideas. This book describes what happens when innovations are transferred to new settings: What work is needed to make them work, but also how they change the setting into which they are introduced.

This paper describes one style of functional analysis commonly used in the neurosciences called task-bound functional analysis. The concept of function invoked by this style of analysis is distinctive in virtue of the dependence relations it bears to transient environmental properties. It is argued that task-bound functional analysis cannot explain the presence of structural properties in nervous systems. An alternative concept of neural function is introduced that draws on the theoretical neuroscience literature, and an argument is given to show that (...) this alternative concept of may help to overcome the explanatory limitations of task-bound functional analysis. (shrink)

Interrogating received knowledge is constitutive to any critical project, and recently there has been a wave of scholarship which argues for locating the origin of racist-thinking prior to modern Europe—even prior to the Common Era—without any real consideration of the potential dangers accompanying such a seismic redefinition. By expanding “racism” to include potentially any pre-modern xenophobic or ethnicist atrocity, even well-meaning scholarship dilutes the peculiar injustice of modern Europe’s most successful epistemological weapon. As a result, we lose any criteria to (...) distinguish ubiquitous oppressive projects from specifically racist-projects of hegemony and domination. However laudable its intent, such scholarship falls prey to methodological, epistemological, and practical errors that hamstring the ameliorative impact of contemporary anti-racist work while ironically diminishing racism’s impact. For if every conflict is racist, then contemporary colorblindness is correct: if white supremacy isn’t particularly white, then racism is a distinction without a difference. (shrink)

In the late 19th century, physiologists such as David Ferrier, Eduard Hitzig, and Hermann Munk argued that cerebral brain functions are localized in discrete structures. By the early 20th century, this became the dominant position. However, another prominent physiologist, Friedrich Goltz, rejected theories of cerebral localization and argued against these physiologists until his death in 1902. I argue in this paper that previous historical accounts have failed to comprehend why Goltz rejected cerebral localization. I show that Goltz adhered (...) to a falsificationist methodology, and I reconstruct how he designed his experiments and weighted different kinds of evidence. I then draw on the exploratory experimentation literature from recent philosophy of science to trace one root of the debate to differences in how the German localizers designed their experiments and reasoned about evidence. While Goltz designed his experiments to test hypotheses about the functions of predetermined cerebral structures, the localizers explored new functions and structures in the process of constructing new theories. I argue that the localizers relied on untested background conjectures to justify their inferences about functional organization. These background conjectures collapsed a distinction between phenomena they produced direct evidence for (localized symptoms) and what they reached conclusions about (localized functions). (shrink)

BackgroundThe neural activity and functional networks of emotion-based cognitive reappraisal have been widely investigated using electroencephalography and functional magnetic resonance imaging. However, single-mode neuroimaging techniques are limited in exploring the regulation process with high temporal and spatial resolution.ObjectivesWe proposed a source localization method with multimodal integration of EEG and fMRI and tested it in the source-level functional network analysis of emotion cognitive reappraisal.MethodsEEG and fMRI data were simultaneously recorded when 15 subjects were performing the emotional cognitive reappraisal task. Fused (...) priori weighted minimum norm estimation with sliding windows was proposed to trace the dynamics of EEG source activities, and the phase lag index was used to construct the functional brain network associated with the process of downregulating negative affect using the reappraisal strategy.ResultsThe functional networks were constructed with the measure of PLI, in which the important regions were indicated. In the gamma band source-level network analysis, the cuneus, the lateral orbitofrontal cortex, the superior parietal cortex, the postcentral gyrus, and the pars opercularis were identified as important regions in reappraisal with high betweenness centrality.ConclusionThe proposed multimodal integration method for source localization identified the key cortices involved in emotion regulation, and the network analysis demonstrated the important brain regions involved in the cognitive control of reappraisal. It shows promise in the utility in the clinical setting for affective disorders. (shrink)

Globalization cuts both ways. Not only does it valorize the local in a cultural sense, it constructs the local as the tribal. Processes of geopolitical fragmentation give those in power even more room to manoeuvre. Glocalization involves the reallocation of poverty and stigma from above without even the residual responsibility of noblesse oblige. Geographical and social mobility are dichotomized; populations are refigured as tourists and vagabonds. Globalization thus reinforces already existing patterns of domination, while globalization indicates trends to dispersal and (...) conflict on neo-traditional grounds. The privileged walk, or fly away; the others take revenge upon each other. (shrink)

GianCarlo Ghirardi passed away on June 1st, 201. He would have turned 83 on October 28, 2018. He was without any doubt one of the most prominent theoretical physicists working on the foundation and the philosophy of quantum mechanics. In this paper I review some of his achievements and underline how his research influenced the philosophy of physics community.

This paper is concerned with n-localization property introduced by Newelski and Rosłanowski in [10] and getting it for CS iterations of forcing notions.